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A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
Thermal modelling using discrete vasculature for thermal therapy: A review
H Petra Kok1, Johanna Gellermann, Cornelis A T van den Berg
1Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands. H.P.Kok@amc.uva.nl
Accurate 3D temperature monitoring is crucial for hyperthermia and thermal ablation. Thermal modeling with discrete vasculature offers improved treatment planning and real-time feedback for better patient outcomes.
Area of Science:
- Medical Physics
- Biomedical Engineering
- Oncology
Background:
- Conventional temperature measurements lack 3D information crucial for hyperthermia and thermal ablation.
- Effective treatment control relies on precise temperature data during these therapies.
Purpose of the Study:
- To review advancements in thermal modeling using discrete vasculature for hyperthermia and thermal ablation planning.
- To highlight the importance of blood perfusion in thermal redistribution within tissues.
Main Methods:
- Review of thermal modeling techniques, focusing on discrete vasculature.
- Analysis of the impact of blood perfusion on thermal simulations.
- Examination of progress in real-time simulation capabilities.
Main Results:
- Significant progress has been achieved in thermal modeling with discrete vasculature.
- Real-time simulations are now feasible, enabling intra-treatment feedback.
- Discrete vasculature modeling enhances the accuracy of thermal simulations.
Conclusions:
- Thermal modeling with discrete vasculature is vital for improving hyperthermia and thermal ablation treatment planning.
- Real-time simulations promise enhanced therapeutic feedback and control.
- Future clinical integration is expected to elevate treatment quality in thermal therapies.
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