Related Experiment Video
Updated: May 10, 2026

Synthesis of Compound Giant Unilamellar Vesicles: A Biomimetic Model of Nucleate Cells
Published on: July 3, 2025
Influence of surface chemistry on particle internalization into giant unilamellar vesicles
Jiaojiao Liu1, Naiyan Lu, Jingliang Li
1Center for Soft Condensed Matter Physics and Interdisciplinary Research, Soochow University, Suzhou, 215006, PR China.
Abstract:
Cellular uptake of materials plays a key role in their biomedical applications. In this work, based on the cell-mimic giant unilamellar vesicles (GUVs) and a novel type of microscale materials consisting of stimuli-responsive poly(N-isopropylacrylamide) microgel particles and the incorporated lipids, the influence of particle surface chemistry, including hydrophobic/hydrophilic property and lipid decorations, on the adsorption and consequent internalization of particles into GUVs was investigated. It is found that the decoration of particle surface with lipids facilitates the adsorption of particles on GUV membrane. After that, the hydrophobic property of particle surface further triggers the internalization of particles into GUVs. These results demonstrate the importance of surface properties of particles on their interactions with lipid membranes and are helpful to the understanding of cellular uptake mechanism.
More Related Videos
09:29Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
Published on: January 19, 2020
06:34In vitro Reconstitution of Cytoskeletal Networks inside Phase Separated Giant Unilamellar Vesicles (GUVs)
Published on: June 20, 2025
Related Concept Videos
Micelles
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Pinching-off of Coated Vesicles
Intralumenal Vesicles and Multivesicular Bodies
COP Coated Vesicles
Introduction to Membrane Traffic
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...