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Fullerenol nanoparticles: toxicity and antioxidant activity
Rade Injac1, Matevz Prijatelj, Borut Strukelj
1Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Methods in Molecular Biology (Clifton, N.J.)
|June 7, 2013
Summary
Fullerenes, carbon-based molecules, show promise as antioxidants. Polyhydroxylated fullerene derivatives, like fullerenol nanoform (C60(OH)24), are being studied for their biological activities and potential therapeutic applications.
Area of Science:
- Nanotechnology
- Materials Science
- Biochemistry
Background:
- Fullerenes are spherical carbon molecules discovered in 1985.
- Research investigates fullerene reactivity and biological potential.
- Polyhydroxylated fullerene derivatives (fullerenols) exhibit antioxidative properties.
Purpose of the Study:
- To review published studies on fullerene biological activities.
- To focus on the antioxidative potential of fullerenol nanoform (C60(OH)n).
- To highlight the extensively studied C60(OH)24 nanoform.
Main Methods:
- In vitro and in vivo studies were analyzed.
- Literature review of fullerene biological interactions.
- Focus on studies involving polyhydroxylated fullerene derivatives.
Main Results:
- Fullerenols demonstrate significant antioxidative capabilities in biological systems.
- C60(OH)n nanoforms, particularly C60(OH)24, are effective in combating oxidative stress.
- Evidence supports the potential of fullerenes in biological applications.
Conclusions:
- Polyhydroxylated fullerenes, especially C60(OH)24, are potent antioxidative agents.
- Fullerenes represent a promising class of compounds for biomedical applications.
- Further research into fullerene biological activities is warranted.
