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Updated: May 10, 2026

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Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
Top-down chemoenzymatic approach to a high-mannose-type glycan library: synthesis of a common precursor and its
Akihiko Koizumi1, Ichiro Matsuo, Maki Takatani
1ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Angewandte Chemie (International Ed. in English)
|June 7, 2013
Abstract:
From the stacks: A novel method for construction of a high-mannose-type glycan library by systematic enzymatic trimming of a single synthetic Man9-based precursor was developed. Efficient chemical synthesis of the tetradecasaccharide common precursor and orthogonal enzymatic trimming to obtain all M(8-9) and G(1)M(8-9) derivatives was demonstrated. G = glucose, M = mannose.

