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Updated: May 10, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Dual PI3K/mTOR inhibitors: does p53 modulate response?
Oleksandr Ekshyyan1, Arunkumar Anandharaj, Cherie-Ann O Nathan
1Department of Otolaryngology/Head and Neck Surgery and Feist-Weiller Cancer Center, LSU Health Sciences Center, Shreveport, Louisiana 71130, USA.
Genetic alterations in head and neck squamous cell carcinomas impact treatment response. Evaluating these distinct changes helps identify patients who benefit from targeted therapies, improving outcomes and reducing side effects.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Head and neck squamous cell carcinomas (HNSCC) are characterized by numerous genetic alterations.
- These molecular changes can significantly affect patient responses to various treatment modalities.
- Understanding these alterations is crucial for personalized medicine approaches in HNSCC.
Purpose of the Study:
- To investigate the impact of specific genetic alterations in HNSCC on the efficacy of targeted therapies.
- To identify patient subgroups that are most likely to respond positively to targeted treatment strategies.
- To correlate distinct genetic profiles with treatment outcomes, including survival and toxicity.
Main Methods:
- Analysis of genetic alterations in HNSCC patient samples.
- Evaluation of treatment response in relation to identified genetic profiles.
- Correlation of specific molecular alterations with clinical outcomes and adverse events.
Main Results:
- Distinct genetic alterations were found to significantly influence response to targeted agents in HNSCC.
- Identification of specific molecular markers associated with improved treatment efficacy.
- Correlation between certain genetic profiles and reduced treatment-related toxicity.
Conclusions:
- Targeted therapy selection based on distinct genetic alterations can optimize HNSCC treatment.
- Personalizing treatment strategies according to HNSCC molecular profiles can improve patient survival.
- Identifying responsive patient subsets minimizes unnecessary toxicity and enhances therapeutic benefit.
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