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Updated: May 10, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
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Published on: March 23, 2022

Morbihan syndrome.

Stefano Veraldi1, Maria Chiara Persico, Claudia Francia

  • 1Department of Pathophysiology and Transplantation, University of Milan, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Indian Dermatology Online Journal
|June 7, 2013
PubMed
Summary

This case study details severe Morbihan syndrome, a facial swelling condition. Oral isotretinoin treatment proved ineffective for this chronic erythematous edema.

Keywords:
AcneMorbihan diseaseMorbihan syndromechronic erythematous edema of the faceisotretinoinrosacea

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Area of Science:

  • Dermatology
  • Clinical Case Study

Background:

  • Morbihan syndrome is a rare condition causing chronic facial edema.
  • Understanding its clinical presentation and histopathology is crucial for diagnosis.

Observation:

  • A 60-year-old male presented with severe Morbihan syndrome affecting the forehead, glabella, and eyelids, impairing vision.
  • Erythema and telangiectasias were noted on the nose and cheeks.
  • Standard laboratory and instrumental tests were unremarkable.

Findings:

  • Histopathology revealed dermal edema, lympho-histiocytic infiltrate, and sebaceous gland hyperplasia.
  • The patient's severe symptoms persisted despite a 26-week course of oral isotretinoin.

Implications:

  • This case highlights the potential ineffectiveness of oral isotretinoin for severe Morbihan syndrome.
  • Further research into effective treatments for this debilitating condition is warranted.