Related Experiment Video
Updated: May 10, 2026

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
A case of intracranial hemorrhage causing stress-induced cardiomyopathy
Leslie Russell1, Philip Stockwell
1Internal medicine resident at The Warren Alpert Medical School at Brown University.
Insights
Intracranial hemorrhage can trigger stress-induced cardiomyopathy, mimicking Takotsubo
Area of Science:
- Cardiology
- Neurology
Background:
- Takotsubo cardiomyopathy involves left ventricular dysfunction and apical ballooning without coronary disease.
- Intracranial hemorrhage is a recognized cause of stress-induced cardiomyopathy.
Observation:
- This case highlights a patient experiencing polymorphic ventricular tachycardia due to subarachnoid hemorrhage-induced stress-cardiomyopathy.
- Neurogenic cardiac damage shares pathophysiological mechanisms with other stress-induced cardiomyopathies.
Findings:
- Subarachnoid hemorrhage can precipitate severe cardiac events like ventricular tachyarrhythmias.
- Neurogenic stress-induced cardiomyopathy typically shows good cardiovascular prognosis with rapid echocardiographic resolution.
Implications:
- Understanding the link between neurological events and cardiac dysfunction is crucial for diagnosis and management.
- This case underscores the potential for severe, albeit rare, cardiac manifestations of neurological emergencies.
Abstract:
The classic finding of Takotsubo's cardiomyopathy is left ventricular systolic dysfunction with echocardiographic evidence of apical ballooning in the absence of significant coronary disease. Intracranial hemorrhage is a known cause for stress-induced cardiomyopathy with a similar echocardiographic presentation. This diagnostic finding suggests a similar pathophysiologic mechanism between neurogenic cardiac damage and the wide array of medical and psychosocial disorders that are known to cause stress-induced cardiomyopathy (Takotsubo's syndrome). The neurogenic-cardiac variant of stress-induced cardiomyopathy is associated with good cardiovascular prog- nosis; the hallmark feature of the disorder is complete echocardiographic resolution of systolic dysfunction within a short period of time. While malignant presentations are rare, the disorder can present as severe heart failure or ventricular tachyarrhythmias. We report a case of a near life-threatening episode of polymorphic ventricular tachycardia due to a subarachnoid hemorrhage (SAH)-induced stress-cardiomyopathy.
Related Concept Videos
Hemorrhagic Stroke l: Introduction
Hemorrhagic Stroke ll: Pathophysiology
Myocarditis I: Introduction
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiomyopathy I: Introduction and Classification
Cardiomyopathy II: Dilated Cardiomyopathy
