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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Asthma: Pathogenesis and Management

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Related Experiment Video

Updated: May 10, 2026

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium

Published on: February 21, 2025

Caveolin-1 controls airway epithelial barrier function. Implications for asthma.

Tillie-Louise Hackett¹, Harold G de Bruin, Furquan Shaheen

¹1 University of British Columbia James Hogg Research Centre, Heart and Lung Institute, St. Paul's Hospital, Vancouver, British Columbia, Canada; and.

American Journal of Respiratory Cell and Molecular Biology

|June 8, 2013

Summary

Reduced caveolin-1 in asthma airways impairs epithelial barrier function and promotes allergic responses. Restoring caveolin-1 improves barrier integrity and reduces pro-allergic cytokine release, highlighting its therapeutic potential.

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Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies

Published on: December 26, 2012

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Last Updated: May 10, 2026

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium

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Published on: February 21, 2025

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies

Published on: December 26, 2012

Area of Science:

Cell Biology
Immunology
Respiratory Medicine

Background:

Airway epithelial fragility in asthma is not fully understood.
Caveolin-1 stabilizes adherens junctions and may be involved in asthma pathogenesis.

Purpose of the Study:

To investigate the role of caveolin-1 in asthma-related epithelial barrier dysfunction.
To determine if reduced caveolin-1 contributes to increased pro-allergic activity in asthma.

Main Methods:

Studied caveolin-1, E-cadherin, and β-catenin expression in asthma patient airway sections and cultured cells.
Manipulated caveolin-1 levels in human bronchial epithelial cell lines (16HBE, BEAS-2B) to assess effects on barrier function and TSLP production.

Main Results:

Lower membrane caveolin-1 expression in asthma airways, maintained in vitro.
Reduced caveolin-1 correlated with loss of E-cadherin/β-catenin, impaired barrier function, and increased thymic stromal lymphopoietin (TSLP).
Caveolin-1 down-regulation caused E-cadherin delocalization and barrier dysfunction; overexpression improved barrier function and reduced TSLP.

Conclusions:

Caveolin-1 is crucial for epithelial cell-cell adhesion and maintaining airway barrier integrity in asthma.
Loss of caveolin-1 contributes to airway dysfunction and promotes Th2-mediated allergic inflammation in asthma.
Targeting caveolin-1 may offer a therapeutic strategy for improving asthma control.