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Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation
Published on: January 7, 2021
Potential of magnetic resonance for imaging the fetal heart
Alice Wielandner1, Elisabeth Mlczoch, Daniela Prayer
1Department of Radiology, Medical University of Vienna, AKH, Vienna, Austria.
Insights
Significant congenital heart disease (sCHD) affects newborns, making it a leading cause of infant death. Fetal MRI offers a promising complementary tool to echocardiography for prenatal diagnosis of cardiac and vascular abnormalities.
Area of Science:
- Medical Imaging
- Cardiology
- Prenatal Diagnosis
Background:
- Significant congenital heart disease (sCHD) is a major cause of neonatal death, necessitating accurate prenatal detection.
- Prenatal diagnosis of cardiac abnormalities aids in parental counseling and perinatal management.
- Echocardiography (ECG) is the standard for fetal cardiac assessment but can be limited by image quality and operator experience.
Purpose of the Study:
- To review the potential of fetal magnetic resonance imaging (MRI) in delineating fetal heart anatomy and pathologies.
- To explore how fetal MRI can complement echocardiography in detecting cardiovascular and extracardiac lesions.
- To discuss the limitations of current fetal cardiac MRI and ongoing developments to overcome them.
Main Methods:
- Review of existing literature on fetal cardiac MRI.
- Analysis of the capabilities of MRI in assessing fetal cardiovascular anatomy and disease.
- Identification of challenges in fetal cardiac imaging, such as fetal heart rate and movement.
Main Results:
- Fetal MRI shows potential to complement ultrasound in detecting cardiovascular malformations and extracardiac lesions.
- Current fetal cardiac MRI is not routine but is emerging as a valuable second-line approach.
- Ongoing developments aim to address limitations like fast fetal heart rates and fetal motion.
Conclusions:
- Fetal MRI is a developing tool with significant potential to enhance the prenatal diagnosis of congenital heart disease.
- Further advancements in MRI technology are crucial for routine clinical application in fetal cardiac imaging.
- Combining fetal MRI with echocardiography may improve the comprehensive assessment of fetal cardiac conditions.
Abstract:
Significant congenital heart disease (sCHD) affects 3.6 per 1000 births, and is often associated with extracardiac and chromosomal anomalies. Although early mortality has been substantially reduced and the rate of long-term survival has improved, sCHD is, after preterm birth, the second most frequent cause of neonatal infant death. The prenatal detection of cardiac and vascular abnormalities enables optimal parental counselling and perinatal management. Echocardiography (ECG) is the first-line examination and gold standard by which cardiac malformations are defined. However, adequate examination by an experienced healthcare provider with modern technical imaging equipment is required. In addition, maternal factors and the gestational age may lower the image quality. Fetal magnetic resonance imaging (MRI) has been implemented over the last several years and is already used in the clinical routine as a second-line approach to assess fetal abnormalities. MRI of the fetal heart is still not routinely performed. Nevertheless, fetal cardiac MRI has the potential to complement ultrasound in detecting cardiovascular malformations and extracardiac lesions. The present work reviews the potential of MRI to delineate the anatomy and pathologies of the fetal heart. This work also deals with the limitations and continuing developments designed to overcome the current problems in cardiac imaging, including fast fetal heart rates, the lack of ECG-gating, and the presence of fetal movements.
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