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Caffeine-containing medicines increase the risk of hemorrhagic stroke

Seung-Mi Lee1, Nam-Kyong Choi, Byung-Chul Lee

  • 1Chung-Ang University College of Pharmacy, Seoul, South Korea.

Stroke
|June 8, 2013
PubMed

Insights

Caffeine-containing medicines (CCMs) are linked to a higher risk of hemorrhagic stroke (HS). This study found CCM use increased HS risk, particularly for non-coffee drinkers.

Area of Science:

  • Neurology
  • Pharmacology
  • Epidemiology

Background:

  • Limited research exists on the association between caffeine-containing medicines (CCMs) and hemorrhagic stroke (HS) risk.
  • Understanding this relationship is crucial for public health and patient safety.

Purpose of the Study:

  • To investigate the association between the use of caffeine-containing medicines (CCMs) and the risk of hemorrhagic stroke (HS).

Main Methods:

  • A multicenter case-control study was conducted in South Korea between 2002 and 2004.
  • Included 940 patients with acute HS and matched controls, analyzing medication use within 14 days prior to stroke onset.
  • Conditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs).

Main Results:

  • CCM use was associated with a significantly increased risk of HS (OR, 2.23; 95% CI, 1.41-3.69).
  • This association was observed for both subarachnoid hemorrhage (OR, 2.24; 95% CI, 1.08-4.66) and intracerebral hemorrhage (OR, 2.49; 95% CI, 1.29-4.80).
  • The risk was higher in individuals who did not consume coffee daily (OR, 2.95; 95% CI, 1.45-5.98).

Conclusions:

  • The findings suggest a positive association between the use of caffeine-containing medicines and an elevated risk of hemorrhagic stroke.
  • This includes both subarachnoid and intracerebral hemorrhage subtypes.
  • The increased risk may be more pronounced in individuals with lower habitual coffee intake.
Abstract

Keywords:
caffeinecase-control studiescerebral hemorrhagesubarachnoid hemorrhage

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