Related Experiment Video
Updated: May 10, 2026
12:21
MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
Published on: November 30, 2013
MicroRNAs in arterial hypertension
Andreas Synetos1, Konstantinos Toutouzas, Konstantinos Stathogiannis
1First Department of Cardiology, University of Athens, Medical School, 7 E. Makariou Str., Paleo Psychico, 15452, Athens, Greece. synetos@yahoo.com
Current Topics in Medicinal Chemistry
|June 11, 2013
Summary
Arterial hypertension affects nearly a billion people globally. MicroRNAs (miRNAs) are crucial in regulating gene expression and are implicated in hypertension
Area of Science:
- Cardiovascular Science
- Molecular Biology
- Genetics
Background:
- Arterial hypertension is a widespread epidemic with severe health consequences.
- MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
- miRNAs play significant roles in various biological processes, including cardiovascular health.
Purpose of the Study:
- To investigate the role of specific microRNAs (miRNAs) in the pathogenesis of arterial hypertension.
- To identify key miRNAs involved in hypertension for improved understanding and treatment.
Main Methods:
- Analysis of miRNA expression profiles in hypertension models.
- Bioinformatic analysis to predict miRNA targets and pathways.
- Validation of miRNA involvement in cellular processes relevant to hypertension.
Main Results:
- Specific miRNAs were found to be dysregulated in arterial hypertension.
- These miRNAs target key genes involved in blood pressure regulation and cardiovascular remodeling.
- Functional studies confirmed the impact of identified miRNAs on cellular pathways implicated in hypertension.
Conclusions:
- MicroRNAs are critical players in the development and progression of arterial hypertension.
- Identifying key miRNAs offers potential for novel diagnostic biomarkers.
- Targeting specific miRNAs may lead to new therapeutic strategies for hypertension management.
Related Concept Videos
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
01:29Hypertension II: Pathophysiology
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
01:25Antihypertensive Drugs: Direct Renin Inhibitors
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
01:18Neural Regulation of Blood Pressure
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...