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Extraction and Analysis of Taiwanese Green Propolis

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Published on: January 7, 2019

Phytochemicals targeting genes relevant for type 2 diabetes.

Carani Venkatraman Anuradha¹

¹Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar - 608 002, Tamil Nadu, India. cvaradha@hotmail.com

Canadian Journal of Physiology and Pharmacology

|June 11, 2013

Summary

Nutrigenomics shows diet can impact type 2 diabetes mellitus (T2DM) by influencing genes. Understanding nutrient-gene interactions offers personalized T2DM treatment strategies.

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Area of Science:

Nutrigenomics
Molecular Biology
Genetics

Background:

Type 2 diabetes mellitus (T2DM) is a complex, multifactorial disease with a significant genetic component.
Insulin resistance and beta cell dysfunction characterize T2DM, a growing global epidemic.
Individual differences in T2DM susceptibility and treatment response are linked to genetic variations like single nucleotide polymorphisms.

Purpose of the Study:

To review the genetic aspects of T2DM.
To explore how nutrients modify genes relevant to diabetes.
To discuss future prospects for nutritional therapy in T2DM management.

Main Methods:

Literature review focusing on nutrigenomics, ethnopharmacology, and phytotherapy.
Analysis of studies on bioactive food components and their interaction with the genome.
Identification of phytochemicals targeting diabetogenic genes.

Main Results:

Dietary interventions show promise for managing T2DM based on nutrigenomic principles.
Bioactive food components can influence cellular processes and disease progression.
Phytochemicals from medicinal plants demonstrate potential in targeting diabetogenic genes.

Conclusions:

Understanding nutrient-gene interactions is crucial for developing individualized T2DM interventions.
Nutritional therapy holds significant future potential for T2DM treatment.
Ethnobotanical knowledge can guide the discovery of novel T2DM therapeutic agents.