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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Published on: February 13, 2016

Smart drug release systems based on stimuli-responsive polymers.

Guangyan Qing1, Minmin Li, Lijing Deng

  • 1State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 430070 Wuhan, PR China.

Mini Reviews in Medicinal Chemistry
|June 11, 2013
PubMed
Summary

Stimuli-responsive polymers offer precise drug delivery by changing structure in response to external triggers. This intelligent system enhances accuracy and efficiency while preventing damage to healthy tissues.

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
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Area of Science:

  • Polymer Science
  • Materials Science
  • Biomedical Engineering

Background:

  • Stimuli-responsive polymers undergo reversible transformations upon exposure to external stimuli like temperature, pH, or light.
  • These polymers provide a versatile platform for developing advanced drug delivery systems.
  • Current limitations in drug delivery include low accuracy and potential damage to healthy tissues.

Purpose of the Study:

  • To review recent advancements in drug release systems utilizing stimuli-responsive polymers.
  • To highlight the intelligent and accurate drug delivery capabilities of these systems.
  • To discuss smart polymer-nanoparticle conjugates and devices for sustained drug release.

Main Methods:

  • Literature review of recent progress in stimuli-responsive polymer-based drug delivery.
  • Analysis of polymer transformations induced by various external stimuli.
  • Examination of smart nanoparticles-polymers conjugates and drug release devices.

Main Results:

  • Stimuli-responsive polymers enable highly accurate and efficient drug release.
  • These materials effectively prevent potential damage to normal cells and tissues.
  • Nanoparticle-polymer conjugates and specialized devices facilitate long-term sustained drug release.

Conclusions:

  • Stimuli-responsive polymers represent a significant breakthrough in controlled drug delivery.
  • Intelligent drug release systems enhance therapeutic efficacy and patient safety.
  • Future applications include advanced formulations for chronic disease management.