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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Allergic Reactions02:06

Allergic Reactions

Overview
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

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Related Experiment Video

Updated: May 10, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

Ephrins and pain.

Ioanna Vasileiou1, Ioannis Adamakis, Efstratios Patsouris

  • 1Laiko University Hospital, Medical School, First Department of Anesthesiology, 75, Mikras Asias street, GR11527, Goudi, Athens, Greece.

Expert Opinion on Therapeutic Targets
|June 11, 2013
PubMed
Summary

The ephrin system, a key player in cell signaling, is increasingly linked to various pain conditions. Targeting these ephrin receptors (Eph-receptors) shows promise for developing novel pain therapeutics.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • The ephrin receptor family, comprising 14 members (A and B subclasses), are receptor tyrosine kinases.
  • Ephrin receptors interact with various membrane receptors, influencing cell communication.
  • Growing evidence implicates ephrins/Eph receptors in modulating diverse pain types.

Purpose of the Study:

  • To review current literature on ephrins and their role in pain modulation.
  • To explore the therapeutic potential of targeting the ephrin/Eph receptor system for pain management.

Main Methods:

  • Comprehensive literature review.
  • Synthesis of recent data on ephrin/Eph receptor involvement in pain.
  • Analysis of potential therapeutic strategies.

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Determining heat and mechanical pain threshold in inflamed skin of human subjects
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Determining heat and mechanical pain threshold in inflamed skin of human subjects

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Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
08:39

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on: May 16, 2022

Related Experiment Videos

Last Updated: May 10, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
08:39

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on: May 16, 2022

Main Results:

  • The ephrin/Eph receptor system is implicated in the pathophysiology of numerous pain conditions.
  • Modulation of this system offers potential therapeutic avenues for various pain states.

Conclusions:

  • The ephrin/Eph receptor system represents an emerging target for pain drug discovery.
  • Further investigation into selective agonists and antagonists is warranted for therapeutic development.