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Published on: May 30, 2013

The role of T cell immunity in HIV-1 infection

C Mee Ling Munier¹, Anthony D Kelleher, Stephen J Kent

¹The Kirby Institute for Infection and Immunity in Society, University of NSW, Sydney, NSW, Australia.

Current Opinion in Virology

|June 11, 2013

Abstract:

The interplay between the T cell immune response and human immunodeficiency virus (HIV)-1 largely determines the outcome of infection. Typically, the virus overcomes the immune defences leading to a gradual decline in function that permits the development of disease. In recent years, a concerted effort in comparing T cell responses between 'controllers' and 'progressors' is beginning to identify the T cell subsets and factors that affect disease progression related to the effector functions of both CD4 and CD8 T cells. These efforts are providing opportunities for development of novel therapies and vaccines.

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