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Activity of Drill® lozenges on the main microorganisms responsible for upper respiratory tract infections

C Michel1, S Salvatico1, H Belkhelfa1

  • 1Fonderephar, faculté des sciences pharmaceutiques, 35, chemin des Maraîchers, 31062 Toulouse cedex 9, France.

European Annals of Otorhinolaryngology, Head and Neck Diseases
|June 11, 2013
PubMed
Abstract

Insights

Drill® lozenges demonstrate significant in vitro antimicrobial and antiviral efficacy against common upper respiratory tract pathogens. These findings support their use in treating infections like sore throat, complementing antibiotic-free approaches.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Sore throat is often viral, not requiring antibiotics.
  • Topical treatments like lozenges offer localized relief.
  • Throat lozenges provide immediate and sustained release of active ingredients.

Purpose of the Study:

  • To evaluate the in vitro antimicrobial and antiviral effectiveness of Drill® lozenges.
  • To assess both short-term and long-term efficacy against key respiratory pathogens.
  • To support the use of topical antiseptics in upper respiratory tract infections.

Main Methods:

  • Bactericidal and virucidal activity testing against major respiratory pathogens, including H1N1 influenza virus.
  • Evaluation of efficacy after short (5 minutes) and long (3 hours) contact times.
  • Assessment of antibacterial activity on resident flora using maximum inhibitory and bactericidal dilutions.

Main Results:

  • Drill® lozenges showed significant antibacterial activity (>90% pathogen destruction) within 5 minutes at high concentration and after 3 hours when diluted.
  • Effective antiviral activity against H1N1 virus (2 log destruction) within 5 minutes, maintained after dilution for 3 hours.
  • Homogeneous antibacterial effect observed on the resident flora.

Conclusions:

  • In vitro results confirm Drill® lozenges' value in treating upper respiratory tract infections.
  • Chlorhexidine-based lozenges are effective against common sore throat pathogens.
  • Supports topical antiseptic use as an alternative to antibiotics for viral infections.
Keywords:
ChlorhexidineH1N1 virusSore throatUpper respiratory tract infections

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