Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

Cirrhosis I: Introduction

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

Myasthenia Gravis ll: Pathophysiology

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

Microbiome of the Eye

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The prognostic role of inhalation injury in burn patients assessed by flexible bronchoscopy: a systematic review and meta-analysis.

Frontiers in medicine·2026

Same author

Impact of Driver Genetic Alterations on Survival in Metastatic Colorectal Cancer Patients from a Genetically Homogeneous Sardinian Population: A Real-World Study.

Cancers·2026

Same author

Oxidative Stress Biomarkers in Silicosis: A Systematic Review.

Diseases (Basel, Switzerland)·2026

Same author

A RETROSPECTIVE ANALYSIS OF RISK FACTORS FOR RESPIRATORY FAILURE IN SILICOSIS PATIENTS EXPOSED TO GRANITE DUST.

Journal of occupational and environmental medicine·2026

Same author

Elevated serum trimethylamine N-oxide (TMAO) and trimethyllysine in patients with amyotrophic lateral sclerosis (ALS): An exploratory case-control study.

IBRO neuroscience reports·2026

Same author

Neopterin in inflammation and oxidative stress.

Advances in clinical chemistry·2026

Search research articles

Related Experiment Video

Updated: May 10, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Meibomian gland dysfunction and hypercholesterolemia.

Antonio Pinna¹, Francesco Blasetti¹, Angelo Zinellu²

¹Department of Surgical, Microsurgical, and Medical Sciences, Section of Ophthalmology, University of Sassari, Sassari, Italy.

|June 11, 2013

Summary

This summary is machine-generated.

Meibomian gland dysfunction (MGD) in patients aged 18-54 is significantly linked to higher cholesterol levels, suggesting MGD may indicate undiagnosed hypercholesterolemia. This finding could enhance early cardiovascular disease risk detection by ophthalmologists.

More Related Videos

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Published on: April 1, 2019

Related Experiment Videos

Last Updated: May 10, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Published on: April 1, 2019

Area of Science:

Ophthalmology
Cardiovascular Health
Metabolic Disorders

Background:

Hypercholesterolemia is a major risk factor for cardiovascular diseases.
Meibomian gland dysfunction (MGD) is a common cause of chronic blepharitis.
Elevated cholesterol in glandular secretions is hypothesized to contribute to MGD development.

Purpose of the Study:

To investigate the correlation between MGD and hypercholesterolemia in young and middle-aged adults (18-54 years).

Main Methods:

An observational, case-control pilot study was conducted.
Sixty MGD patients and 63 controls without MGD or hypercholesterolemia were recruited.
Fasting blood levels of total cholesterol, LDL, HDL, triglycerides, glucose, and creatinine were measured.

Main Results:

Hypercholesterolemia was present in 58.3% of MGD cases versus 6.3% of controls (P < 0.0001).
MGD was significantly associated with higher total cholesterol (OR, 1.07), LDL (OR, 1.07), and HDL (OR, 1.11) levels.
Mean total cholesterol, LDL, and HDL levels were significantly higher in MGD cases compared to controls.

Conclusions:

Young and middle-aged patients with MGD may exhibit higher blood cholesterol levels.
MGD could serve as a marker for previously undiagnosed hypercholesterolemia.
Ophthalmologists may play a role in the early detection of cardiovascular disease risk factors through MGD identification.