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Updated: May 10, 2026

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
Published on: December 9, 2022
A radical signal activates the epigenetic regulation of longevity
Mario G Mirisola1, Valter D Longo2
1Department of Medical and Forensic Biotechnology (DiBiMeF), University of Palermo, via Divisi 83, 90133 Palermo, Italy; Longevity Institute, School of Gerontology and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.
Abstract:
Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.
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