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Related Experiment Video

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RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem
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A review on ochratoxin A transcriptomic studies.

Ariane Vettorazzi1, Joost van Delft, Adela López de Cerain

  • 1Department of Pharmacology and Toxicology, University of Navarra, 31008 Pamplona, Spain. avettora@unav.es

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|June 11, 2013
PubMed
Summary

Ochratoxin A (OTA) is a kidney carcinogen. Transcriptomic reviews show gene expression changes, with some genes upregulated in vivo related to cell injury and proliferation, while others are downregulated, suggesting complex mechanisms.

Keywords:
Gene expressionMicroarraysMycotoxinOchratoxin AToxicogenomicsTranscriptomics

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Area of Science:

  • Toxicology
  • Genomics
  • Molecular Biology

Background:

  • Ochratoxin A (OTA) is a mycotoxin with established renal carcinogenicity in male rats.
  • Transcriptomic studies offer insights into the molecular mechanisms of OTA toxicity.

Purpose of the Study:

  • To review and analyze transcriptomic data from in vitro and in vivo studies of Ochratoxin A.
  • To elucidate the molecular pathways and mechanisms underlying OTA-induced renal toxicity and carcinogenicity.

Main Methods:

  • Systematic review of 6 in vivo and 4 in vitro transcriptomic studies on Ochratoxin A.
  • Analysis of gene expression patterns, focusing on pathways related to DNA damage, cell injury, apoptosis, oxidative stress, and metabolism.

Main Results:

  • A general downregulation of gene expression was observed, potentially due to protein synthesis inhibition.
  • In vivo studies showed upregulation of genes linked to acute renal injury, cell survival, and proliferation.
  • Apoptosis genes were deregulated in vitro, MAPK activation was noted, and genes for OTA transport and metabolism were downregulated in vivo.

Conclusions:

  • The precise mechanism of Ochratoxin A's action remains incompletely understood.
  • Transcriptomic data provide valuable insights for generating new mechanistic hypotheses and comparing in vitro and in vivo findings.