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Exploring the Potential of Mesenchymal Stem Cell Sheet on The Development of Hepatocellular Carcinoma In Vivo
Published on: September 11, 2018
Bone marrow mesenchymal stem cells in hepatocellular carcinoma
Peng Gong1, Yingxin Wang, Jing Zhang
1Department of Hepatobiliary Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian, China. doctorgongpeng@yeah.net
Frontiers in Bioscience (Landmark Edition)
|June 11, 2013
Summary
Bone marrow mesenchymal stem cells (BMSCs) may drive hepatocellular carcinoma (HCC) development and progression. Targeting these cells offers a promising therapeutic strategy for HCC treatment and prevention.
Area of Science:
- Stem cell biology
- Oncology
- Hepatocellular carcinoma research
Background:
- Bone marrow mesenchymal stem cells (BMSCs) are multipotent stem cells with potential roles in cancer.
- Animal models suggest BMSCs may be implicated in the origin of hepatocellular carcinoma (HCC).
- BMSCs influence the tumor microenvironment through cytokine secretion, promoting tumor growth and metastasis.
Purpose of the Study:
- To review the role of human BMSCs in the pathogenesis of hepatocellular carcinoma (HCC).
- To explore the therapeutic potential of targeting BMSCs for HCC treatment and prevention.
Main Methods:
- Literature review of studies on BMSCs and HCC.
- Analysis of mechanisms by which BMSCs influence HCC.
- Evaluation of therapeutic strategies targeting BMSCs in HCC.
Main Results:
- Evidence suggests genetically mutated BMSCs can initiate HCC.
- BMSCs modulate the tumor microenvironment, promoting HCC initiation, growth, and homing.
- BMSCs are identified as a potential target for molecular therapies against HCC.
Conclusions:
- Human BMSCs play a significant role in HCC pathogenesis.
- Targeting BMSCs presents a viable therapeutic avenue for managing and preventing HCC.
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