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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

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Related Experiment Video

Updated: May 10, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Nanoparticles as 'smart' pharmaceutical delivery.

Chiranjib Chakraborty1, Soumen Pal, George Priya C Doss

  • 1Department of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater noida, India. drchiranjib@yahoo.com

Frontiers in Bioscience (Landmark Edition)
|June 11, 2013
PubMed
Summary
This summary is machine-generated.

This review explores nanoparticle delivery systems for pharmaceuticals, detailing their types, properties, and applications. It covers targeted drug delivery, cancer therapy, and vaccine development, including current clinical trials.

Related Experiment Videos

Last Updated: May 10, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Area of Science:

  • Pharmaceutical Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Nanoparticle-based drug delivery systems are rapidly advancing.
  • Understanding their characteristics and properties is crucial for pharmaceutical applications.

Purpose of the Study:

  • To provide a comprehensive understanding of nanoparticle delivery systems.
  • To review pharmaceutical ingredient loading and release mechanisms.
  • To highlight diverse applications of these systems.

Main Methods:

  • Literature review of nanoparticle delivery systems.
  • Analysis of system properties, loading, and release kinetics.
  • Survey of current and emerging pharmaceutical applications.

Main Results:

  • Detailed overview of various nanoparticle types and their characteristics.
  • Discussion of key properties influencing drug delivery efficacy.
  • Exploration of applications including brain, ocular, oral, dermal, and transdermal delivery.
  • Coverage of cancer chemotherapy, vaccine, and nucleic acid delivery.
  • Inclusion of nanoparticle-coupled implants and clinical trial data.

Conclusions:

  • Nanoparticle delivery systems offer versatile and promising platforms for advanced pharmaceutical applications.
  • Further research and clinical trials are essential to realize their full potential.
  • These systems are poised to revolutionize targeted drug delivery and therapeutic outcomes.