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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
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Evidence for a relation between plasma membrane coenzyme Q and autism.

Frederick L Crane1, Hans Low, Iris L Sun

  • 1Department of Biological Sciences, Purdue University, W. Lafayette, Indiana, USA. flccoq10@aol.com

Frontiers in Bioscience (Elite Edition)
|June 11, 2013
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Voltage Dependent Anion Channel (VDAC) may play a role in autism development. Increased antibodies to VDAC in autistic children inhibit its functions, suggesting a novel link between VDAC activity and autism pathogenesis.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Neuroscience

Background:

  • Voltage Dependent Anion Channel (VDAC) facilitates transport across cell membranes.
  • VDAC also functions as a transmembrane NADH dehydrogenase.
  • Autism is associated with increased antibodies targeting VDAC proteins.

Purpose of the Study:

  • Investigate the potential role of VDAC function in autism development.
  • Explore the coenzyme Q requirement for VDAC's dehydrogenase activity in erythrocyte membranes.

Main Methods:

  • Analysis of VDAC antibody levels in autistic children.
  • Assessment of VDAC transport and dehydrogenase activities.
  • Investigation of coenzyme Q requirement for erythrocyte membrane dehydrogenase.

Main Results:

  • Autistic children exhibit elevated antibodies against VDAC.
  • Antibody binding inhibits both VDAC transport and NADH dehydrogenase activities.
  • Erythrocyte membrane dehydrogenase activity requires coenzyme Q, suggesting a novel VDAC function.

Conclusions:

  • VDAC's function may be implicated in the pathogenesis of autism.
  • Coenzyme Q is essential for VDAC's dehydrogenase activity in erythrocyte membranes.
  • This finding offers a new perspective on VDAC's role in cellular metabolism and disease.