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Updated: May 10, 2026
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Published on: May 7, 2011
Association between angiotensin-converting enzyme I/D polymorphism and sepsis: A meta-analysis
Summary
The angiotensin-converting enzyme I/D polymorphism is linked to a reduced risk of developing sepsis. However, this genetic variation does not appear to influence sepsis-related mortality rates.
Area of Science:
- Genetics
- Molecular Biology
- Critical Care Medicine
Background:
- Inconsistent findings exist regarding the association between the angiotensin-converting enzyme (ACE) I/D polymorphism and sepsis risk.
- Previous studies have yielded conflicting results, necessitating a comprehensive review.
Purpose of the Study:
- To conduct a meta-analysis to clarify the association between the ACE I/D polymorphism and sepsis risk.
- To investigate the relationship between the ACE I/D polymorphism and sepsis-related mortality.
Main Methods:
- A systematic literature search was conducted across multiple databases.
- Six case-control studies and two cohort studies were included in this meta-analysis.
- Random-effects models were employed to estimate pooled odds ratios and 95% confidence intervals.
Main Results:
- The meta-analysis revealed a significant association between the ACE I/D polymorphism and sepsis risk under a recessive genetic model (OR = 0.75, 95% CI: 0.62-0.91, p = 0.004).
- No statistically significant association was found between the ACE I/D polymorphism and sepsis-related mortality (OR = 0.84, 95% CI: 0.57-1.24, p = 0.38).
Conclusions:
- The ACE I/D polymorphism is confirmed to be associated with an altered risk of developing sepsis.
- The ACE I/D polymorphism does not appear to be a significant predictor of mortality in sepsis patients.
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