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Single molecule SERS and detection of biomolecules with a single gold nanoparticle on a mirror junction
Li Li1, Tanya Hutter, Ullrich Steiner
1Institute for Life Sciences, Highfield Campus, University of Southampton, SO17 1BJ, UK.
Abstract:
Using the bianalyte method we unambiguously demonstrate that a single gold nanosphere on a metal film junction, in the so-called nanoparticle on a mirror configuration, is capable of single molecule detection with surface-enhanced Raman spectroscopy (SERS). Also this configuration serves as a convenient and highly sensitive SERS sensor for detection of biomolecules. Such simple nano-junction based systems are ideal for chemical and biomedical analysis.
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