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Updated: May 10, 2026

Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method
Published on: May 12, 2023
[Study on optimal processing technology of three kinds of processed coptidis rhizoma]
De-Zhen Wang1, Jun Yi, Yi Zhang
1College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. wangdezhen88@163.com
Objective:
To optimize the processing technology of Coptidis Rhizoma and study the effects of different adjuvants on alkaloids during processing.
Methods:
The moistening time of adjuvants (A), processing temperature (B) and processing time (C) were investigated by using the single factor test method and L9 (3(4)) orthogonal experiment design with the contents of four alkaloids as indexes.
Results:
The sequence of importance of the factors that affect the wine processed Coptidis Rhizoma (WC) was C > B > A, turmeric processed Coptidis Rhizoma (TC) and dogwood processed Coptidis Rhizoma (DC) was B > A > C.
Conclusion:
The optimal processing technology of WC, TC and DC are drying for 4 h at 130 degrees C after moistening for 90 min, drying for 3 h at 100 degrees C after moistening for 60 min and drying for 2 h at 160 degrees C after moistening for 90 min, respectively.
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