[The induction of specific dicentric chromosomes in CHO-6 Chinese hamster ovary cells]

Under a long treatment of cells CHO-6 with 5-bromodeoxyuridine and colcemid it was discovered that dicentric chromosomes in metaphases of the first division of polykaryocytes contained micronuclei. When the cells were treated with colcemid only, the number of dicentrics was less. This phenomenon was described earlier in the Chinese hamster cell line B11d-ii FAF28. Under the similar testing of continuous cell lines of human, swine, African green monkey and Syrian hamster origin this result failed be reproduced. From the data of experiments it was testified that the phenomenon in question may be very likely the characteristics of all the Chinese hamster continuous cell lines.