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Simultaneous cryptococcal and tuberculous meningitis in a patient with systemic lupus erythematosus
Bilgul Mete1, Nese Saltoglu1, Ersin Vanli1
1Department of Infectious Diseases and Clinical Microbiology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
Abstract:
Simultaneous central nervous system (CNS) infection with Cryptococcus and tuberculosis (TB) is very rare. Despite improved therapeutic options, treatment of CNS cryptococcosis is still difficult and needs invasive treatment modalities, such as intrathecal or intraventricular amphotericin B, in refractory cases. We describe a patient with systemic lupus erythematosus diagnosed with simultaneous cryptococcal and TB meningitis who had a poor response to intravenous liposomal amphotericin B and fluconazole, but was successfully treated with intraventricular amphotericin B, in addition to anti-TB therapy.
Insights
Simultaneous central nervous system (CNS) infection with Cryptococcus and tuberculosis (TB) is rare. Intraventricular amphotericin B successfully treated a patient with co-existing CNS cryptococcal and TB meningitis unresponsive to other therapies.
Area of Science:
- Neuroscience
- Infectious Diseases
- Immunology
Background:
- Simultaneous central nervous system (CNS) infection by Cryptococcus and tuberculosis (TB) is exceptionally rare.
- Treatment of CNS cryptococcosis presents challenges, often requiring invasive methods for refractory cases.
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