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Updated: May 10, 2026
09:35
Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
Commentary on special issue: CNS diseases and the immune system
Bert A 't Hart1, Wilfred F den Dunnen
1Department Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ, Rijswijk, The Netherlands. hart@bprc.nl
Summary
The immune system plays a role in central nervous system (CNS) diseases, but mechanisms are unclear. This review explores immune roles in CNS disorders, suggesting the immune system as a potential therapeutic target for untreatable conditions.
Area of Science:
- Neuroimmunology
- Central Nervous System (CNS) Disorders
Background:
- Growing evidence suggests immune system involvement in various CNS diseases.
- The precise mechanisms underlying immune system contribution to CNS pathology remain largely unknown.
Purpose of the Study:
- To provide a comprehensive review of current knowledge on immune mechanisms in CNS disorders.
- To foster discussion on the potential of targeting the immune system for novel therapeutic strategies.
Main Methods:
- Review of adaptive and innate immune system components.
- Analysis of immune players in the context of multiple CNS disorders.
Main Results:
- Adaptive and innate immunity are implicated in CNS disease pathogenesis.
- Specific immune cells and pathways are key players in neurological conditions.
Conclusions:
- The immune system represents a promising therapeutic avenue for CNS diseases.
- Further research into neuroimmunology could lead to effective treatments for currently intractable conditions.
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