The Forgotten Brother: The Innate-like B1 Cell in Multiple Sclerosis
Saar T Halperin1, Bert A 't Hart1, Antonio Luchicchi1
1Department of Anatomy and Neurosciences, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam UMC, Vrije Universiteit, 1081 HZ Amsterdam, The Netherlands.
Biomedicines
|March 25, 2022
Summary
Multiple sclerosis (MS) involves central nervous system (CNS) damage. This review explores B1 lymphocytes, immune cells in the brain, and their potential role in MS pathogenesis and novel therapies.
Area of Science:
- Neuroimmunology
- Central Nervous System (CNS) Disorders
- Autoimmune Diseases
Background:
- Multiple sclerosis (MS) is a neurodegenerative CNS disease.
- Traditionally viewed as an autoimmune attack on myelin.
- Emerging evidence suggests CNS-initiated pathology may trigger MS autoimmunity.
Purpose of the Study:
- To explore the role of B1 lymphocytes in MS.
- To investigate B1 cell function in healthy and MS brains.
- To propose therapeutic strategies targeting B1 cells.
Main Methods:
- Review of existing literature on B1 lymphocytes and MS.
- Analysis of B1 cell frequency and function in MS patients versus controls.
- Discussion of potential dysregulation of B1 cell homeostasis in MS.
Main Results:
- B1 cells are natural antibody and anti-inflammatory cytokine producers in the healthy brain.
- B1 cell frequency and function may differ between MS patients and healthy individuals.
- The precise involvement of B1 cells in MS pathogenesis is currently unclear.
Conclusions:
- B1 lymphocytes may play a significant, underappreciated role in MS pathology.
- Dysregulation of B1 cell homeostasis could impact MS.
- Targeting B1 cell beneficial functions offers novel therapeutic avenues for MS.
Keywords:
B1 cellautoantibodiesautoimmunityinnate-like lymphocytesmultiple sclerosisnatural antibodiesneurodegenerationMore Related Videos
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