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Updated: May 10, 2026

An In Vivo Murine Sciatic Nerve Model of Perineural Invasion
Published on: April 23, 2018
Perineural spread of cervical cancer to the sciatic nerve
Benjamin Matthew Howe1, Kimberly K Amrami, Mark A Nathan
1Department of Radiology, Mayo Clinic, Charlton 2-290, 200 First Street SW, Rochester, MN, 55905, USA, howe.benjamin@mayo.edu.
Abstract:
In this report we present a patient with a recent diagnosis of cervical adenocarcinoma with progressive left lower extremity pain and weakness. MR imaging of the pelvis and subsequent FDG CT/PET were complementary in demonstrating abnormalities worrisome for perineural spread of malignancy, which was confirmed with an open fascicular biopsy of the sciatic nerve. We review the imaging and propose a mechanism of perineural spread to the sciatic nerve, which we believe is supported by the imaging in this case.
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