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Related Concept Videos

Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...

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Updated: May 10, 2026

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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A fully integrated prothrombin time test on the microfluidic disk analyzer.

Chia-Hui Lin1, Chih-Hsin Shih, Chien-Hsing Lu

  • 1Department of Chemical Engineering, Feng Chia University, 100 Wenhwa Road, Taichung 40724, Taiwan.

Journal of Nanoscience and Nanotechnology
|June 13, 2013
PubMed
Summary
This summary is machine-generated.

This study presents an integrated microfluidic disk for prothrombin time testing, enabling rapid plasma separation and mixing. The novel device demonstrated good correlation with a standard analyzer, offering a potential advancement in coagulation diagnostics.

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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Area of Science:

  • Biomedical Engineering
  • Clinical Diagnostics
  • Microfluidics

Background:

  • Prothrombin time (PT) testing is crucial for assessing blood coagulation and monitoring anticoagulant therapy.
  • Current methods can be time-consuming and require complex laboratory setups.
  • There is a need for rapid, integrated, and potentially point-of-care coagulation testing solutions.

Purpose of the Study:

  • To develop and evaluate a fully integrated microfluidic disk system for prothrombin time (PT) measurement.
  • To assess the efficiency of plasma extraction and rapid mixing functionalities on the microfluidic disk.
  • To validate the performance of the microfluidic disk analyzer against a standard clinical coagulation analyzer.

Main Methods:

  • Development of a microfluidic disk incorporating plasma extraction and rapid mixing capabilities.
  • Investigation of factors influencing the plasma decanting mechanism for efficient sample processing.
  • Comparative analysis of PT results obtained from the microfluidic disk analyzer and a Sysmex CA1500 analyzer using 92 whole blood clinical samples.

Main Results:

  • The microfluidic disk successfully integrated plasma extraction and rapid mixing within 1 second.
  • Factors affecting the plasma decanting mechanism were systematically investigated and optimized.
  • Excellent correlation and agreement were observed between the microfluidic disk analyzer and the Sysmex CA1500 for prothrombin time measurements.

Conclusions:

  • The fully integrated microfluidic disk system provides an efficient and reliable method for prothrombin time testing.
  • The device demonstrates potential for rapid and accurate coagulation analysis, comparable to established laboratory instruments.
  • This microfluidic approach represents a promising advancement for clinical diagnostics in coagulation monitoring.