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Updated: May 10, 2026

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
Published on: September 24, 2021
[Medication of the month. asenapine (Sycrest]
1Service de Psychiatrie et de Psychologie Médicale, CHU de Liège, Belgique. wpitchot@chu.ulg.ac.be
Abstract:
Asenapine is a new atypical antipsychotic. Like other atypicals, asenapine acts as an antagonist at both dopamine D2 and serotonin 5-HT2A receptors. The efficacy of asenapine monotherapy in the treatment of bipolar disorder manic episodes in adults has been demonstrated in two similarly designed randomized placebo-controlled flexible-dose trials of 3 weeks' duration, using olanzapine as active reference. Asenapine is associated with a good tolerability profile. In particular, asenapine induces a moderate weight gain, and does not increase serum levels of lipids or fasting glucose.
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