Related Experiment Video
Updated: May 10, 2026

14:49
Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration
Published on: September 29, 2018
Younger patients report greater improvement in self-reported function after knee joint replacement.
Brian D Street1, Wesley Wong, Michael Rotondi
1Orthopaedic Neuromechanics Laboratory, School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada.
The Journal of Orthopaedic and Sports Physical Therapy
|June 13, 2013
Summary
Younger patients (50-59) showed the greatest improvement after knee replacement surgery. The Oxford Knee Score effectively predicts the need for surgery, particularly in younger individuals.
Area of Science:
- Orthopedics
- Geriatric Medicine
- Health Outcomes Research
Background:
- Growing number of younger patients undergoing knee replacement surgery.
- Limited understanding of functional outcomes in younger cohorts post-surgery.
- Need to explore age-related differences in joint function after knee replacement.
Purpose of the Study:
- Evaluate age-related changes in Oxford Knee Score (OKS) post-total knee replacement (TKR).
- Determine if preoperative OKS predicts TKR indication.
- Investigate the influence of age on the OKS-indication relationship.
Main Methods:
- Retrospective chart review of 240 patients.
- Utilized the Oxford Knee Score questionnaire for pain and dysfunction assessment.
- Analyzed OKS changes from pre- to post-operative assessments.
Main Results:
- Youngest group (50-59 years) experienced the most significant improvement in OKS.
- OKS was the strongest predictor (OR=0.61) for TKR indication.
- Younger patients had higher preoperative OKS scores indicating surgery compared to older patients (80-89 years).
Conclusions:
- Age significantly influences self-perceived joint function before and after TKR.
- Findings support the use of OKS as a preoperative tool for knee osteoarthritis treatment decisions.
- Results inform clinical decisions regarding surgical options for younger patients.