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Updated: May 10, 2026

A Protocol for the Production of KLRG1 Tetramer
07:24

A Protocol for the Production of KLRG1 Tetramer

Published on: January 12, 2010

Structural basis for R-spondin recognition by LGR4/5/6 receptors

Dongli Wang1, Binlu Huang, Senyan Zhang

  • 1Ministry of Education Key Laboratory of Protein Science, Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, PR China.

Genes & Development
|June 13, 2013
PubMed
Summary

Researchers elucidated how R-spondin proteins (RSPO1-RSPO4) bind to LGR4 receptors. This structural insight reveals the molecular mechanism for Wnt pathway activation, crucial for development and stem cell growth.

Keywords:
Wnt signalcomplexligand/receptor interaction

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