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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Related Experiment Video

Updated: May 10, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

[Symptoms and therapy for steroid glaucoma].

F Rüfer1, D Uthoff

  • 1Augenheilkunde, Augenklinik Bellevue, Lindenalle 21/23, Kiel. f.ruefer@augenklinik-bellevue.de

Klinische Monatsblatter Fur Augenheilkunde
|June 13, 2013
PubMed
Summary

Steroid medications can cause high intraocular pressure (IOP) by depositing in the eye's drainage system. This steroid-induced glaucoma affects many primary open-angle glaucoma patients and requires specific diagnosis and treatment.

Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Topical or systemic steroids can cause extracellular deposits in the trabecular meshwork, increasing outflow resistance.
  • 30-40% of the general population are steroid responders, with 5% developing significant intraocular pressure (IOP) rise (>15 mmHg), termed high responders.
  • Approximately 90% of primary open-angle glaucoma (POAG) patients are steroid responders.

Purpose of the Study:

  • To review the pathophysiology, diagnosis, and treatment of steroid-induced glaucoma.
  • To highlight the high prevalence of steroid response in POAG patients.
  • To discuss differential diagnoses and management strategies for steroid glaucoma.

Main Methods:

  • Literature review of steroid-induced glaucoma.
  • Analysis of steroid response prevalence in normal and POAG populations.

Related Experiment Videos

Last Updated: May 10, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

  • Discussion of diagnostic criteria, including IOP recompensation after steroid cessation.
  • Overview of treatment options: topical medications, surgery, and potential future therapies.

    • Main Results:

    • Dexamethasone exhibits the highest IOP-increasing potency among steroids.
    • Steroid response extent varies with steroid type and duration of use.
    • Diagnosis relies on detailed patient history and IOP normalization post-steroid withdrawal.
    • Treatment options include medical, surgical, and laser interventions, with limited comparative studies.

    Conclusions:

    • Steroid-induced glaucoma is a significant concern, particularly in POAG patients.
    • Accurate diagnosis through history and IOP monitoring is crucial.
    • Management involves standard glaucoma treatments, with surgical removal of steroid deposits considered for refractory cases.
    • Gene therapy represents a potential future research avenue for steroid glaucoma.