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The oxidative and antioxidative status of simple febrile seizure patients

Mahmut Abuhandan1, Mustafa Calik, Abdullah Taskin

  • 1Department of Paediatrics, Medical Faculty, Harran University, Sanliurfa, Turkey. drabuhandan@mynet.com

JPMA. the Journal of the Pakistan Medical Association
|June 14, 2013
PubMed

Insights

Children experiencing simple febrile seizures show increased oxidative stress. This study found higher total oxidant levels and a lower total antioxidant level, suggesting a potential increased risk for these seizures.

Area of Science:

  • Pediatric Neurology
  • Biochemistry

Background:

  • Febrile seizures are common in children.
  • Oxidative stress plays a role in various neurological conditions.

Purpose of the Study:

  • To investigate the oxidative status in children following a simple febrile seizure.
  • To determine if oxidative stress markers differ between children with febrile seizures and healthy controls.

Main Methods:

  • Cross-sectional study involving 32 children with simple febrile seizures and 30 healthy controls.
  • Blood samples collected within 8 hours post-seizure.
  • Measured total oxidant level, total antioxidant level, and calculated oxidative stress index using the Erel technique.

Main Results:

  • Children with simple febrile seizures exhibited significantly higher total oxidant levels (p < 0.01).
  • The oxidative stress index was significantly elevated in the patient group (p < 0.01).
  • Total antioxidant levels were significantly lower in children with febrile seizures compared to controls (p < 0.03).

Conclusions:

  • Febrile seizures are associated with increased oxidative stress, indicated by elevated oxidant levels and reduced antioxidant capacity.
  • This imbalance in oxidative status may contribute to the pathophysiology or recurrence risk of febrile seizures.
Abstract

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