Related Experiment Video
Updated: May 10, 2026
A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
Published on: December 28, 2013
Measurement of anesthetic uptake kinetics in the brain using (19)F MRI and cross-correlation analysis after pulsed
Maxim Terekhov1, Alexander Scholz, Laura M Schreiber
1Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany, terekhov@uni-mainz.de.
Object:
We present a pilot study based on (19)F-MRI to measure fast and slow wash-in and wash-out kinetics of volatile anesthetics in pig brain.
Method:
The periodic administration of anesthetics in pulsed mode is used to enhance the sensitivity of the anesthetic concentration detection by (19)F-MRI signal. Temporal correlation analysis allows mapping the kinetics time constants.
Results:
The clear correlation response to anesthetics concentration changes was found in the brain region in comparison with fatty tissues.
Conclusion:
The methodology may yield important pharmacological findings on regional effect of the anesthetics in brain and be a step towards human studies.
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