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Updated: May 10, 2026
06:55
Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
Locally aggressive fibrous dysplasia
T G Kashima1, N M Gamage, H Ye
1Department of Histopathology, NDORMS, University of Oxford, Oxford, UK.
Virchows Archiv : an International Journal of Pathology
|June 14, 2013
Summary
Fibrous dysplasia (FD) can rarely behave aggressively, extending into soft tissues. Distinguishing aggressive FD from osteosarcoma involves checking for GNAS mutations and the absence of CDK4/MDM2 amplification.
Area of Science:
- Pathology
- Oncology
- Genetics
Background:
- Fibrous dysplasia (FD) is typically a benign fibro-osseous lesion.
- Locally aggressive behavior in FD is rare and poorly understood.
Observation:
- This study examined three cases of locally aggressive FD, two involving ribs.
- Follow-up ranged from 2-7 years, including one recurrent lesion.
- All lesions showed typical FD histology but extended through bone cortex into soft tissue.
Findings:
- Aggressive FD lesions lacked CDK4 and MDM2 overexpression/amplification.
- A GNAS mutation was identified in two of the three cases.
- These findings confirm rare aggressive behavior in FD with extra-osseous extension.
Implications:
- Aggressive FD can be differentiated from low-grade osteosarcoma.
- Distinguishing features include GNAS mutation presence and lack of CDK4/MDM2 amplification.
- This aids in accurate diagnosis and appropriate management of rare aggressive FD cases.
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