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Published on: November 28, 2019
Plasmacytoid dendritic cells and regulatory T cells in the tumor microenvironment: A dangerous liaison
Curdin Conrad1, Michel Gilliet
1Department of Dermatology; University Hospital CHUV; Lausanne, Switzerland.
Abstract:
Tumor-infiltrating plasmacytoid dendritic cells (pDCs) have been associated with poor patient prognosis. We have recently uncovered the ability of pDCs to activate and expand a subset of tumor-infiltrating FOXP3+ regulatory T cells that express inducible costimulator (ICOS), providing new insights into the mechanisms that govern the escape of cancer from immunosurveillance.
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