Prognostic value of the immune microenvironment in lung adenocarcinoma
Kyuichi Kadota1, Jun-Ichi Nitadori, Prasad S Adusumilli
1Division of Thoracic Service; Department of Surgery; Memorial Sloan-Kettering Cancer Center; New York, NY USA ; Department of Diagnostic Pathology; Faculty of Medicine; Kagawa University; Kagawa, Japan.
Oncoimmunology
|June 14, 2013
Abstract:
We analyzed the immune microenvironment in the neoplastic and stromal components of Stage I lung adenocarcinoma lesions, finding that a high ratio of tumor-infiltrating FOXP3+ regulatory T cells to CD3+ lymphocytes, an elevated expression of the interleukin-7 receptor, as well as a reduced expression of the interleukin-12 receptor β2 all constitute independent factors of poor prognosis.

