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Updated: May 10, 2026

In Vitro Assay to Study Tumor-macrophage Interaction
Published on: August 1, 2019
Remote control of macrophage production by cancer
Virna Cortez-Retamozo1, Camilla Engblom, Mikael J Pittet
1Center for Systems Biology; Massachusetts General Hospital and Harvard Medical School; Boston, MA USA.
Abstract:
The communication between tumor and host cells involves signals that act across extended distances in the body. Recent evidence indicates that the hormone angiotensin II is overproduced by lung adenocarcinoma to remotely expand bone marrow-derived hematopoietic stem cells. This process amplifies the supply of tumor-associated macrophages, which promote disease progression.
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