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Attenuated measles virus used as an oncolytic virus activates myeloid and plasmacytoid dendritic cells

Jean-François Fonteneau1, Jean-Baptiste Guillerme, Frédéric Tangy

  • 1INSERM; UMR892; Nantes, France ; CNRS; UMR6299; Nantes, France ; Université de Nantes; Nantes, France.

Oncoimmunology
|June 14, 2013
PubMed

Insights

Attenuated measles viruses (MV) show promise in cancer treatment by targeting tumor cells. MV-infected cells can also boost the immune system

Area of Science:

  • Oncology
  • Immunology
  • Virology

Background:

  • Attenuated measles viruses (MV) are being investigated for cancer therapy.
  • MV exhibit tumor-selective infection and killing capabilities.
  • Previous research suggests a role for MV in modulating the immune system.

Purpose of the Study:

  • To evaluate the potential of measles virus (MV)-based antitumor virotherapy.
  • To determine if MV-infected tumor cells can stimulate an antitumor immune response.

Main Methods:

  • Clinical trials assessing attenuated measles viruses (MV).
  • Investigating the interaction between MV-infected tumor cells and dendritic cells.
  • Analyzing tumor antigen cross-presentation by myeloid and plasmacytoid dendritic cells.

Main Results:

  • Measles virus (MV)-infected tumor cells activate tumor antigen cross-presentation.
  • Myeloid and plasmacytoid dendritic cells are involved in this activation process.

Conclusions:

  • Measles virus (MV)-based virotherapy has the potential to stimulate a robust antitumor immune response.
  • This approach may enhance the efficacy of cancer treatments by leveraging the immune system.
Keywords:
cytotoxic CD8+ T cellmeasles virus vaccinemyeloid DConcolytic virusplasmacytoid DCtumor antigen

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