Related Experiment Video

Updated: May 10, 2026

Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

Prostate cancer vaccines: Update on clinical development

Sean M Geary1, Aliasger K Salem

  • 1Department of Pharmaceutical Sciences and Experimental Therapeutics; College of Pharmacy; University of Iowa; Iowa City, IA USA.

Oncoimmunology
|June 14, 2013
PubMed

Insights

Prostate cancer vaccines show promise as a safe alternative or supplement to standard treatments for advanced prostate cancer. These therapies generate immune responses with potential antitumor activity in patients with castration-resistant prostate cancer.

Area of Science:

  • Oncology
  • Immunology
  • Vaccine Development

Background:

  • Prostate cancer is a prevalent malignancy in elderly men.
  • Metastatic prostate cancer is currently incurable.
  • Castration-resistant prostate cancer (CRPC) requires novel therapeutic strategies.

Purpose of the Study:

  • To review clinical trials of prostate cancer vaccines over the last 12 years.
  • To provide updates on ongoing prostate cancer vaccine studies.
  • To assess the safety and efficacy of prostate cancer vaccines.

Main Methods:

  • Systematic review of clinical trials.
  • Analysis of vaccine-induced T lymphocyte responses.
  • Evaluation of potential antitumor activity.

Main Results:

  • Prostate cancer vaccines demonstrate safety in clinical trials.
  • Vaccines induce prostate-specific T lymphocyte responses.
  • Evidence suggests potential antitumor activity.

Conclusions:

  • Prostate cancer vaccines may offer alternative or supportive therapies for CRPC.
  • Further research and ongoing studies are crucial.
  • Vaccines represent a promising avenue in prostate cancer treatment.
Keywords:
DNA VaccinesGVAX-PCaProstVac VFSipuleucil-Tcell-based prostate cancer vaccinesclinical trialsgene-mediated cytotoxic immunotherapyprostate cancerviral-based prostate cancer vaccines

More Related Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...