Related Experiment Videos
[Influence of hypoxen on acetylsalicylic acid efficiency in acute inflammation]
Abstract:
Rats were treated by subplantar injections of 0.1 ml 1% carrageenan solution. In 3 hours, this led to the development of acute inflammatory reaction (swelling of legs, neutrophilic leukocytosis, increased erythrocyte sedimentation rate, activation of free-radical oxidation). Acetylsalicylic acid in a dose of 100 mg/kg reduced development of the inflammatory response. Hypoxen in a dose of 50 mg/kg potentiated the effect of acetylsalicylic acid. The injection of both hypoxen and acetylsalicylic acid before the injection of carrageenan produced a strong anti-inflammatory effect, which was manifested by a reliable decrease in all monitored signs of inflammation.
Related Concept Videos
Acute Inflammation II: Local and Systemic Effects
Drugs for Treatment of Ulcerative Colitis in IBD
Acute Inflammation I: Inflammatory Response
Peptic Ulcer Disease II: Pathophysiology
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids
However, this neutralization reaction between...
Phase II Reactions: Acetylation Reactions
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...