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Updated: May 10, 2026

Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
Bilateral diffuse iris atrophy after the use of oral clarithromycin
Paris Tranos1, Mayssa B Nasr, Solon Asteriades
1Retina Eye Center , Thessaloniki , Greece .
Purpose:
To report a newly recognised advert event of clarithromycin.
Methods:
Retrospective, case report.
Results:
A 30-year old female referred to our centre with bilateral diffuse iris atrophy after the use of oral clarithromycin for a pulmonary infection.
Conclusions:
Bilateral acute depigmentation of the iris is a new clinical entity. Iris transillumination and sphincter paralysis are recognised adverse effects of oral antibiotic therapy, but to our knowledge no other publication has referred to uveitis-like syndrome due to oral administration of clarithromycin.
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