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Cognitive-linguistic deficits in euthymic elderly patients with bipolar disorder
Marcia Radanovic1, Paula Villela Nunes, Orestes Vicente Forlenza
1Laboratory of Neuroscience (LIM 27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. marciaradanovic@gmail.com
Journal of Affective Disorders
|June 15, 2013
Summary
Euthymic bipolar disorder patients show persistent language impairments, particularly in syntax and semantics. These deficits impact both language production and comprehension, linking to other cognitive issues in bipolar disorder.
Area of Science:
- Neuroscience
- Psychiatry
- Linguistics
Background:
- Bipolar disorder is increasingly linked to persistent neuropsychological impairments during euthymia, suggesting trait-like features.
- Language and speech abnormalities, especially in verbal fluency and memory, are noted in bipolar disorder.
- Limited research exists on linguistic processing levels (phonological, syntactic, semantic) in euthymic bipolar patients.
Purpose of the Study:
- To investigate phonological, syntactic, and semantic language processing in elderly euthymic bipolar patients.
- To provide a more thorough examination of language deficits in this population.
Main Methods:
- Studied 19 euthymic bipolar patients (aged 60+) and 20 healthy controls.
- Utilized the Arizona Battery for Communication Disorders of Dementia (ABCD) and Test for Reception of Grammar Version 2 (TROG-2).
- Assessed phonological, syntactic, and semantic language domains.
Main Results:
- Bipolar patients exhibited poorer performance in Linguistic Expression (p=0.011).
- Impaired Linguistic Comprehension was observed in Following Commands (p=0.025) and Reading Comprehension of Sentences (p=0.007).
- Poorer results were also found in the TROG-2 (p=0.006).
Conclusions:
- Linguistic impairment, especially in syntax and lexical-semantics, is present in euthymic bipolar patients.
- Deficits affect both language comprehension and production.
- These language issues correlate with other cognitive deficits, including executive functions and episodic memory, in bipolar disorder.
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