Association of baseline high-density lipoprotein levels with restenosis after coronary stenting: a meta-analysis

Previous studies have reported inconsistent results on the association between serum baseline high-density lipoprotein cholesterol (HDL-C) levels and in-stent restenosis (ISR) after coronary stenting.

We searched for studies without language restriction in PubMed, Embase, and the Cochrane library before June 2012. Inverse random weighted meta-analysis was carried out using logarithm of the odds ratio of ISR with its SE to assess the strength of association in each study.

Eight observational studies involving 422 ISR and 1113 non-ISR patients were eligible for our analysis. Overall, there was no association between baseline HDL-C levels and ISR (odds ratio: 1.00, 95% confidence interval: 0.96-1.04). The heterogeneity was not significant between individual studies (P=0.074, I=44.0%) and no publication bias was detected. A sensitivity analysis further confirmed the robustness of results. A similar association was detected in the subgroups with bare metal stent and drug-eluting stent implantation.

Our meta-analysis suggests that serum baseline HDL-C levels are not associated with ISR.