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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Related Experiment Video

Updated: May 10, 2026

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
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Published on: January 19, 2024

Melasma and laser treatment: an evidenced-based analysis.

Shlomit Halachmi1, Merete Haedersdal, Moshe Lapidoth

  • 1Laser Unit, Rabin Medical Center, 7 Keren Kayemet St, Petach Tikva, Israel.

Lasers in Medical Science
|June 15, 2013
PubMed
Summary

Laser treatments for melasma lack consistent safety and efficacy, offering limited improvement duration. Current evidence does not support laser therapy over traditional topical treatments for melasma management.

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Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Photomedicine

Background:

  • Melasma treatment often involves various modalities, with laser therapy being explored.
  • Limited consensus exists on the safety, efficacy, and durability of laser treatments for melasma.
  • Potential risks associated with laser interventions in hyperpigmented skin necessitate risk-benefit analysis.

Purpose of the Study:

  • To systematically review the literature on light-based therapies for melasma.
  • To evaluate the safety, efficacy, and durability of laser treatments compared to conventional approaches.
  • To determine if laser therapy is a recommended treatment for melasma.

Main Methods:

  • Analysis of English language literature focusing on light-based therapy for melasma.
  • Inclusion of prospective, controlled studies with at least 10 participants.
  • Inclusion of studies presenting objective and quantitative data.

Main Results:

  • Seven studies met the inclusion criteria; two used melanin-targeting lasers, five used fractional photothermolysis.
  • Laser treatment response was inconsistent across studies.
  • Adverse events, including hyperpigmentation, were reported.
  • Durability of improvement was limited with laser monotherapy.
  • Laser monotherapy showed no significant benefit over topical treatments in comparative studies.

Conclusions:

  • Laser therapy for melasma is not recommended due to unpredictable safety and efficacy.
  • Limited duration of clinical improvement and lack of clear benefit over conventional treatments support this conclusion.
  • Further research may be needed to establish the role of lasers in melasma management.