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Updated: May 10, 2026

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
09:37

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry

Published on: October 18, 2019

Au-based bimetallic nanoparticles for the intramolecular aminoalkene hydroamination

Sanjay K Singh1, Munendra Yadav, Silke Behrens

  • 1Institut für Anorganische Chemie, Karlsruher Institut für Technologie (KIT) Engesserstr. 15, 76131 Karlsruhe, Germany.

Dalton Transactions (Cambridge, England : 2003)
|June 15, 2013
PubMed

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Carbonyl compounds and primary amines undergo reductive amination first to produce imines, followed by secondary amines in the same reaction mixture, using selective reducing agents like sodium cyanoborohydride or sodium triacetoxyborohydride. Reductive amination produces different degrees of substitution of amines depending on the starting amine substrate.
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Primary amines react with carbonyl compounds—aldehydes and ketones—to generate imines. Imines consist of a C=N double bond and are named Schiff bases after its discoverer—the German chemist Hugo Schiff. On the other hand, secondary amines react with carbonyl compounds to give enamines. In enamines, the presence of a C=C double bond adjacent to the nitrogen atom leads to the delocalization of the lone pair.
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