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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Alternative RNA splicing and cancer

Sali Liu1, Chonghui Cheng

  • 1Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Wiley Interdisciplinary Reviews. RNA
|June 15, 2013
PubMed

Insights

Alternative splicing of pre-messenger RNA (mRNA) generates diverse protein functions. This review covers how altered splicing contributes to cancer development and progression.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Alternative splicing of pre-messenger RNA (mRNA) is a key process generating protein diversity.
  • Dysregulation of alternative splicing is increasingly linked to human diseases, particularly cancer.
  • Understanding these splicing alterations is crucial for cancer biology.

Purpose of the Study:

  • To review recent findings on the role of alternative splicing in cancer.
  • To discuss the mechanisms driving aberrant alternative splicing in cancer cells.

Main Methods:

  • Literature review of recent studies on alternative splicing and cancer.
  • Synthesis of current knowledge on splicing dysregulation in oncogenesis.

Main Results:

  • Alternative splicing plays a critical role in various cancer-associated pathways.
  • Specific splicing patterns are altered in cancer cells, influencing protein function.
  • Mechanisms underlying these alterations are being elucidated.

Conclusions:

  • Alternative splicing is a significant factor in cancer development and progression.
  • Further research into splicing dysregulation mechanisms can reveal novel therapeutic targets.

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